We wish to thanks for the valuable and constructive feed-back about our manuscript. We discussed all the remarks and - wherever correct - amended the manuscript appropriately as indicated.
The amine is generally not Most important; secondary amines which include methylamine or ethylamine, or tertiary cycloalkylamines for instance piperidine and pyrrolidine, are the mostly encountered N-substituents.
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- Verify the routes of metabolism and structures of metabolites acquired beneath influention of different CYP isoforms
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